Epicillin: in vitro laboratory studies.
نویسندگان
چکیده
A new semisynthetic penicillin, structurally related to ampicillin, has been assigned the generic name epicillin, 6-[d-2-amino-2-(1, 4-cyclohexadienyl) acetamido]-penicillanic acid. The antimicrobial spectrum and level of activity of epicillin in vitro are similar to those of ampicillin. In studies with recent clinical isolates, these two antibiotics, when compared with carbenicillin, showed consistently higher antimicrobial activity against Staphylococcus aureus, Streptococcus pyogenes, Escherichia coli, and Proteus species. When tested against Pseudomonas aeruginosa isolates, on the other hand, epicillin exhibited a level of intrinsic activity superior to that of ampicillin but less than that of carbenicillin. Epicillin is an amphoteric substance that is sensitive to penicillinase, is acid-stable, and is minimally, but reversibly, bound to human serum protein.
منابع مشابه
Epicillin: experimental chemotherapy, pharmacodynamics, and susceptibility testing.
Epicillin exhibits excellent therapeutic activity when administered orally or subcutaneously to mice infected with a variety of pathogenic bacteria. These included single strains of Streptococcus pyogenes, non-penicillinase-producing Staphylococcus aureus, Proteus mirabilis, Escherichia coli, Salmonella schottmuelleri, and Pseudomonas aeruginosa, strains of microorganisms selected as typical of...
متن کاملSusceptibility of ampicillin-resistant Haemophilus influenzae to seven penicillins.
Sixty-seven clinical isolates of Haemophilus influenzae from various sections of the United States, England, and Germany were tested for susceptibility to penicillin, ampicillin, amoxicillin, epicillin, carbenicillin, ticarcillin, and methicillin. Fifty-three of the strains had previously been judged to be ampicillin resistant and 14 had been determined to be ampicillin susceptible. Fifty-two o...
متن کاملRadioprotective efficacy of prunus avium fruit in mice brain with reference to in-vitro and in-vivo studies
Background: Radioprotective efficacy of Prunus avium fruit extract (PAE) rich in vitamin A, C, E and anthocyanin was studied against radiation induced biochemical alterations in mice brain. Materials and Methods: In-vitro assays were performed with PAE for its antioxidant studies thereafter for in-vivo study, Swiss albino mice were divided into five groups. Group 1 (control) normal mice. Group ...
متن کامل[Treatment of urinary tract infections with epicillin].
(b) For patients with pronounced clinical features of acute pyelonephritis where rapid control to limit renal damage is desirable. (c) For patients known to have extensive renal damage where there is a danger of infection precipitating renal failure as well as extending the renal lesion. (d) Post-operative patients where oral therapy is impracticable or where absorption is in doubt. Finally, we...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Infection and immunity
دوره 4 1 شماره
صفحات -
تاریخ انتشار 1971